CALL FOR PAPERS Islet Biology Cholecystokinin expression in the -cell leads to increased -cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis
نویسندگان
چکیده
Jeremy A. Lavine,* Carly R. Kibbe,* Mieke Baan, Sirinart Sirinvaravong, Heidi M. Umhoefer, Kimberly A. Engler, Louise M. Meske, Kaitlyn A. Sacotte, Daniel P. Erhardt, and X Dawn Belt Davis School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin; Department of Medicine, Division of Endocrinology, University of Wisconsin-Madison, Madison, Wisconsin; Geriatric Research Education and Clinical Centers, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin
منابع مشابه
Cholecystokinin expression in the β-cell leads to increased β-cell area in aged mice and protects from streptozotocin-induced diabetes and apoptosis.
Cholecystokinin (CCK) is a peptide hormone produced in the gut and brain with beneficial effects on digestion, satiety, and insulin secretion. CCK is also expressed in pancreatic β-cells, but only in models of obesity and insulin resistance. Whole body deletion of CCK in obese mice leads to reduced β-cell mass expansion and increased apoptosis. We hypothesized that islet-derived CCK is importan...
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